Natalia Polouliakh

If anybody tells us that we have to live for 500 years, we can fall into a panic. Considering that our body parts cannot be easily substituted/repaired, everybody will deserve the perfect lifestyle that gives us an opportunity for the continued health.

Efforts to produce practical, affordable, anti-aging arbitrations have recently been increased, leading to some promising compounds, such as metformin, rapamycin, and SIRT1 activators. Biologists report that some endogenous compounds might also have the potential to induce autophagy or endogenously regenerate ES cells, that can turn back the biological clock dramatically.

Skin is quickly gaining visible aging features such as wrinkles, sagging and pigmentation by exposure to the adverse extrinsic factors such as UV radiations, pollution, and rapid temperature change.

Extensive exposure to the sunlight contributes to 85% to skin inflammation upon dehydration, raises stress hormone cortisol that increases the activity of oncogene, that hereafter enhances psoriasis, atopic dermatitis, and cancer.

Also, recent research showed that proteins in the body could reach the brain and echo of inflammation in the brain can be linked to depression, as well Alzheimer's and Parkinson diseases.

I am using the skin cell as an "in vitro" model to monitor age-related disorders and intervene them via combinations of botanical and marine ingredients and lifestyle approaches.

Aging and Disease / Skin / Gene Network



Selected Publications

Natalia Polouliakh and Richard Nock An Advanced Omic Approach to Identify Co-Regulated Clusters and Transcription Regulation Network with AGCT and SHOE MethodsNeuroproteomics: Methods and Protocols, Methods in Molecular Biology,ISBN:1493969501DOI:DOI 10.1007/978-1-4939-6952-4_19Vol:vol. 1598pages 373-389May2017Springer Science+Business Media LLC

Polouliakh, NataliaReprogramming resistant genes: in-depth comparison of gene expressions among iPS, ES and somatic cells.Frontiers in PhysiologyISSN:1664-042XDOI:10.3389/fphys.2013.00007Vol:4No.7pages 1-9January2013

Natalia Polouliakh, Richard Nock, Frank Nielsen, Hiroaki KitanoG-Protein Coupled Receptor Signaling Architecture of Mammalian Immune CellsVol:4 No.1pages e4189PLoS ONEJanuary2009[URL]bow-tie structure, ligand-activated sub-region, spectral clustering


Natalia Polouliakh was born in Russia. She completed her undergraduate studies in the Oriental Languages Department of Irkutsk State Linguistic University. In 1997, she began a master's degree program in the Graduate School of Science and Technology, Hirosaki University, specializing in bioinformatics, and in 2004, she received a Ph.D. from the Institute of Medical Science at Tokyo University. Natalia joined Sony CSL in 2006. She is currently enrolled in a Ph.D. course at the Medical School of Yokohama City University, and she is working on uncovering the mechanisms of skin aging using original data-driven approaches. Her hobbies include yoga, the arts, and fashion.

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