Integrating pathways of Parkinson’s disease in a molecular interaction map

Author

Fujita, Kazuhiro A and Ostaszewski, Marek and Matsuoka, Yukiko and Ghosh, Samik and Glaab, Enrico and Trefois, Christophe and Crespo, Isaac and Perumal, Thanneer M and Jurkowski, Wiktor and Antony, Paul M A and Diederich, Nico and Buttini, Manuel and Kodama, Akihiko and Satagopam, Venkata P and Eifes, Serge and Del Sol, Antonio and Schneider, Reinhard and Kitano, Hiroaki and Balling, Rudi

Abstract

Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd\_map .